This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • General Rhinology  • Neoplasms of Head & Neck  • Prognosis/ Outcomes  • Alert me on articles by topic  Social Bookmarking   What's this?

A Population-Based Analysis of Survival and Prognostic Factors

Daniel Jethanamest, MD; Luc G. Morris, MD; Andrew G. Sikora, MD, PhD; David I. Kutler, MD

Arch Otolaryngol Head Neck Surg. 2007;133(3):276-280.

Objectives  To investigate the characteristics associated with survival in esthesioneuroblastoma and to determine whether the modified Kadish staging system can predict outcome.

Design  Retrospective population-based cohort study.

Subjects  All patients in the Surveillance, Epidemiology, and End Results tumor registry diagnosed as having esthesioneuroblastoma (1973-2002).

Main Outcome Measures  The modified Kadish stage and the overall and disease-specific survival rates were determined.

Results  The cohort included 311 patients with a mean age of 53 years and a unimodal age distribution. The overall 5- and 10-year survival rates were 62.1% and 45.6%, respectively. The modified Kadish staging system was applied to 261 patients. Kaplan-Meier analysis showed the overall and disease-specific survival rates at 10 years to be 83.4% and 90%, respectively, for patients with stage A disease; 49% and 68.3% for patients with stage B disease; 38.6% and 66.7% for patients with stage C disease; and 13.3% and 35.6% for patients with stage D disease. Log-rank test comparisons found Kadish stage (P<.01), treatment modality (P<.002), lymph node status (P<.01), and age at diagnosis (P<.001) to be significant predictors of survival. Cox regression analysis confirmed that Kadish stage remained a significant predictor of disease-specific survival.

Conclusion  The modified Kadish staging system, lymph node status, treatment modality, and age are useful predictors of survival in patients who present with esthesioneuroblastoma.

Author Affiliations: Department of Otolaryngology, New York University School of Medicine, New York, NY (Drs Jethanamest and Morris); Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston (Dr Sikora); and Department of Otorhinolaryngology, Weill Medical College of Cornell University, New York (Dr Kutler).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?