This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Laryngology/ Speech/ Language Pathology  • Neoplasms of Head & Neck  • Pathology of Head & Neck  • Alert me on articles by topic  Social Bookmarking   What's this?

Juan Pablo Rodrigo, MD; Francisco Dominguez, MD; Vanessa Suárez, MD; Marta Canel, PhD; Pablo Secades, PhD; Maria Dolores Chiara, MD, PhD

Arch Otolaryngol Head Neck Surg. 2007;133(2):145-150.

Objective  To explore the value of E-cadherin and focal adhesion kinase (FAK) expression in the prediction of cervical lymph node metastases in squamous cell carcinoma of the supraglottic larynx.

Design  Immunohistochemical analysis of retrospectively selected cases.

Patients  The study population was composed of 95 previously untreated men with squamous cell carcinoma of the supraglottic larynx.

Intervention  All the patients underwent surgical resection of the tumor and bilateral neck dissection.

Main Outcome Measures  E-cadherin and FAK expression in relation to nodal metastases.

Results  Decreased E-cadherin expression was correlated with the presence of nodal metastases (P = .006). The combination of E-cadherin and FAK expression resulted in a superior accuracy in assessing nodal metastasis (P = .001). Histological grade was also associated with nodal metastases (P = .005). Multivariate analysis confirmed that these parameters were independent predictors of nodal metastases. In addition, the cases with decreased E-cadherin and increased FAK expression presented a significantly reduced disease-specific survival (P = .005).

Conclusion  The combination of the expression of E-cadherin and FAK could increase our ability to identify patients with clinically negative lymph nodes who are at considerable risk for occult metastases.

Author Affiliations: Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain (Drs Rodrigo and Suárez); Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo (Drs Rodrigo, Canel, Secades, and Chiara); and Department of Pathology, Hospital Valle del Nalón, Langreo, Spain (Dr Dominguez).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Integrin {alpha}2 Mediates Selective Metastasis to the Liver
Yoshimura et al.
Cancer Res. 2009;69:7320-7328.
ABSTRACT | FULL TEXT  

Targeting Focal Adhesion Kinase with Dominant-Negative FRNK or Hsp90 Inhibitor 17-DMAG Suppresses Tumor Growth and Metastasis of SiHa Cervical Xenografts
Schwock et al.
Cancer Res. 2009;69:4750-4759.
ABSTRACT | FULL TEXT  

Focal Adhesion Kinase as a Therapeutic Target in Cancer
Gan and Siu
Am Soc Clin Oncol Ed Book 2009;2009:130-136.
ABSTRACT | FULL TEXT