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Focal Adhesion Kinase and E-Cadherin as Markers for Nodal Metastasis in Laryngeal Cancer
Juan Pablo Rodrigo, MD;
Francisco Dominguez, MD;
Vanessa Suárez, MD;
Marta Canel, PhD;
Pablo Secades, PhD;
Maria Dolores Chiara, MD, PhD
Arch Otolaryngol Head Neck Surg. 2007;133(2):145-150.
Objective To explore the value of E-cadherin and focal adhesion kinase (FAK) expression in the prediction of cervical lymph node metastases in squamous cell carcinoma of the supraglottic larynx.
Design Immunohistochemical analysis of retrospectively selected cases.
Patients The study population was composed of 95 previously untreated men with squamous cell carcinoma of the supraglottic larynx.
Intervention All the patients underwent surgical resection of the tumor and bilateral neck dissection.
Main Outcome Measures E-cadherin and FAK expression in relation to nodal metastases.
Results Decreased E-cadherin expression was correlated with the presence of nodal metastases (P = .006). The combination of E-cadherin and FAK expression resulted in a superior accuracy in assessing nodal metastasis (P = .001). Histological grade was also associated with nodal metastases (P = .005). Multivariate analysis confirmed that these parameters were independent predictors of nodal metastases. In addition, the cases with decreased E-cadherin and increased FAK expression presented a significantly reduced disease-specific survival (P = .005).
Conclusion The combination of the expression of E-cadherin and FAK could increase our ability to identify patients with clinically negative lymph nodes who are at considerable risk for occult metastases.
Author Affiliations: Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain (Drs Rodrigo and Suárez); Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo (Drs Rodrigo, Canel, Secades, and Chiara); and Department of Pathology, Hospital Valle del Nalón, Langreo, Spain (Dr Dominguez).
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