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Jong Hyouk Lee, MD; Hee Joon Kang, MD; Jeong-Soo Woo, MD; Sung Won Chae, MD; Sang Hag Lee, MD; Soon Jae Hwang, MD; Heung-Man Lee, MD

Arch Otolaryngol Head Neck Surg. 2006;132:537-541.

Objectives  To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa.

Design  Prospective study.

Setting  Tertiary academic institution.

Patients  Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal control subjects.

Interventions  Messenger RNA was extracted from the sinus mucosa, and semiquantitative reverse transcriptase–polymerase chain reaction was performed. Immunohistochemical staining was used to localize the CCL20 protein.

Results  The expression levels of CCL20 messenger RNA level in chronic rhinosinusitis without nasal polyps were significantly increased compared with those in normal sinus mucosa. The expression of CCL20 protein was greater in chronic rhinosinusitis without nasal polyps mucosa and was localized to the epithelial and submucosal glandular cells.

Conclusion  CCL20 is an inducible product of human paranasal sinus epithelium that may play a role in modulating mucosal immunity of the sinus mucosa.

Author Affiliations: Departments of Otorhinolaryngology–Head and Neck Surgery, Hallym University College of Medicine (Dr J. H. Lee) and Korea University College of Medicine (Drs Kang, Woo, Chae, S. H. Lee, Hwang, and H.-M. Lee), Seoul, South Korea.