This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • General Rhinology  • Genetics of Head & Neck Disease  • Paranasal Sinus Disease  • Alert me on articles by topic  Social Bookmarking   What's this?

Yuan-Kai Cheng, MD; Chia-Der Lin, MD; Weng-Cheng Chang, MD, PhD; Guang-Yuh Hwang, PhD; Shih-Wei Tsai, PhD; Lei Wan, PhD; Ming-Hsui Tsai, MD; Jeffrey J. P. Tsai, PhD; Fuu-Jen Tsai, MD, PhD

Arch Otolaryngol Head Neck Surg. 2006;132:285-290.

Objective  To assess the association of the interleukin (IL)-1 and the IL-1 receptor antagonist (IL-1Ra) gene polymorphisms with chronic rhinosinusitis (CRS).

Design  Genotyping of the 2 IL-1 gene (IL1B) polymorphisms (promoter and exon) and the IL-1Ra gene (IL1RN) polymorphism (intron 2) was performed using polymerase chain reaction and restriction length fragment polymorphism analyses.

Setting  Prospective study, tertiary medical center.

Patients  The study population comprised 88 consecutive adult Taiwan-Chinese patients who met stringent criteria for CRS and received endoscopic sinus surgery and 103 healthy volunteers of the same ethnicity and similar age range. Of the 88 patients, 61 had CRS with nasal polyps, while the other 27 had CRS without nasal polyps.

Results  There were significant differences in the distribution of the IL1RN polymorphism between the control subjects and patients with CRS (P<.05). The II allele of IL1RN occurred more frequently in the CRS patient group, and the odds ratio for subjects with I/II genotype was 3.39 (95% confidence interval, 1.25-9.18). In the case of CRS without nasal polyps, the odds ratio for subjects with I/II genotype was further increased to 4.75 (1.39-16.25). There was no association between the other 2 polymorphisms of IL1B and CRS.

Conclusion  Increased prevalence of IL1RN polymorphism in patients with CRS suggests that this polymorphism, or a polymorphism in linkage disequilibrium with it, may be involved in the development of CRS.

Author Affiliations: Departments of Otolaryngology (Drs Cheng, Lin, Chang, and M.-H. Tsai) and Medical Research (Drs Wan and F.-J. Tsai), China Medical University Hospital, Taichung, Taiwan; Department of Life Science, Tunghai University, Taichung (Drs Cheng and Hwang); Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, Taiwan (Dr S.-W. Tsai); and Department of Biotechnology and Bioinformatics, Asia University, Taichung (Dr J.J.P. Tsai).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?