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Up-regulation of Peroxisome Proliferator-Activated Receptor in Perennial Allergic Rhinitis

Hee Joon Kang, MD, PhD; Young-Gi Cinn, MD; Soon Jae Hwang, MD, PhD; Sung Won Chae, MD, PhD; Jeong-Soo Woo, MD, PhD; Sang Hag Lee, MD, PhD; Heung-Man Lee, MD, PhD

Arch Otolaryngol Head Neck Surg. 2006;132:1196-1200.

Objectives  To investigate the expression of peroxisome proliferator-activated receptor (PPAR-) messenger RNA and protein and to localize the PPAR- protein in the nasal mucosa of patients with allergic rhinitis and control subjects.

Design  Prospective study.

Setting  Tertiary academic institution.

Patients  Twenty patients with perennial allergic rhinitis and 20 matched nonallergic patients.

Interventions  Inferior turbinate mucosa samples were obtained from 20 patients with perennial allergic rhinitis and 20 matched nonallegic patients. Peroxisome proliferator-activated receptor messenger RNA was extracted from the inferior turbinate mucosae, and then reverse transcription–polymerase chain reaction was performed. Western blot testing was used to analyze differences in PPAR- protein expression levels between patients with allergic rhinitis and normal controls, and the PPAR- protein was localized immunohistochemically.

Results  The expression levels of PPAR- messenger RNA and protein in the nasal mucosa was significantly increased in patients with perennial allergic rhinitis compared with controls. Peroxisome proliferator-activated receptor protein was expressed in the epithelium, infiltrating inflammatory cells, and submucosal glands.

Conclusions  Peroxisome proliferator-activated receptor is expressed in the human nasal mucosa and is up-regulated in perennial allergic rhinitis. These results suggest a possible contribution for PPAR- in chronic inflammation of the nasal mucosa in perennial allergic rhinitis.

Author Affiliations: Department of Otorhinolaryngology–Head and Neck Surgery, Korea University College of Medicine, Seoul, Republic of Korea.

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