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Incidence and Survival Rates for Young Blacks With Nasopharyngeal Carcinoma in the United States
Luke M. Richey, BA;
Andrew F. Olshan, PhD;
Jonathan George, BA;
Carol G. Shores, MD, PhD;
Adam M. Zanation, MD;
Trinitia Cannon, MD;
Mark C. Weissler, MD
Arch Otolaryngol Head Neck Surg. 2006;132:1035-1040.
Objectives To compare the incidence rates of nasopharyngeal carcinoma (NPC) among US black, white, and Asian/Pacific Islander (Asian) populations, with a focus on those diagnosed before age 20 years and between ages 20 and 29 years. Our secondary objective was to determine differences in survival rates between US blacks, whites, and Asians with NPC who were younger than 30 years.
Design Data from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) tumor registry system were used to determine incidence and survival rates for cases of NPC diagnosed in the specified age groups between 1973 and 2002.
Patients Blacks, whites, and Asians younger than 30 years with NPC.
Main Outcome Measures Incidence rates and 2- and 5-year survival rates.
Results From 1973 to 2002, incidence rates per 1 million persons, adjusted to the 2000 standard population, for blacks, whites, and Asians younger than 20 years with NPC were 1.61 (n = 43), 0.61 (n = 99), and 0.95 (n = 18), respectively. The incidence rate ratio of blacks to Asians younger than 20 years was 1.69 (95% confidence interval [CI], 0.96-3.12) (P = .07), while the rate ratio for blacks to whites was 2.66 (95% CI, 1.82-3.85) (P<.001). From ages 20 to 29 years, rates increased slightly in blacks (1.87) and whites (0.96), while increasing dramatically in Asians (7.18). Two- and 5-year relative survival rates in blacks younger than 30 years were 84% and 64%, respectively, with little variation between races in this age group.
Conclusions Blacks younger than 20 years have increased incidence rates of NPC relative to whites and may be the only group having a higher NPC incidence rate than Asians. Two- and 5-year survival rates of blacks, whites, and Asians younger than 30 years with NPC are similar.
Author Affiliations: General Clinical Research Center (Messrs Richey and George) and Department of Otolaryngology–Head and Neck Surgery (Messrs Richey and George and Drs Olshan, Shores, Zanation, Cannon, and Weissler), University of North Carolina at Chapel Hill School of Medicine; and Department of Epidemiology, University of North Carolina at Chapel Hill School of Public Health (Dr Olshan).
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