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Detection of Labyrinthine Fistulas in Human Temporal Bone by Virtual Endoscopy and Density Threshold Variation on Computed Tomographic Scan
Jean-Loup Bensimon, MD;
Alexis Bozorg Grayeli, MD, PhD;
Michel Toupet, MD;
Evelyne Ferrary, MD;
Olivier Sterkers, MD, PhD
Arch Otolaryngol Head Neck Surg. 2005;131:681-685.
Objective To assess the sensitivity of the routine computed tomographic (CT) scan of the temporal bone coupled to a virtual endoscopy, with density threshold variation, in detecting small fistulas in human temporal bone specimens.
Design Single-blind, before-after trial.
Setting This study was carried out in a research laboratory in collaboration with a radiology department.
Patients Five human adult temporal bone specimens were included.
Interventions The fistulas were created with calibrated burrs (0.3, 0.5, and 0.8 mm) in the 3 semicircular canals and in the promontory of 3 temporal bones. Two other temporal bones served as controls. All bones underwent CT scan (1-mm section thickness) before and after dissection. Three-dimensional images were obtained from CT scan native axial views at different density reconstruction thresholds. The virtual endoscope was placed in the middle ear cavity looking to the inner ear wall. The threshold at which a bony defect appeared on virtual endoscopic images (opening threshold in Hounsfield units [H]) was noted for each location.
Main Outcome Measures Opening thresholds before and after dissection.
Results On standard axial views, fistulas smaller than 0.5 mm were not visualized. By virtual endoscopy, all fistulas could be visualized. The opening threshold decreased after fistula creation in the semicircular canals (1244 ± 50.5 H [n = 36] vs 778 ± 52.4 H [n = 34]; P<.001; 1-way analysis of variance and Dunnett multiple comparisons posttest) and in the promontory (1541 ± 37.8 H [n = 12] vs 1334 ± 35.1 H [n = 8]; P<.001). The opening thresholds in the control specimens remained unchanged after dissection.
Conclusion Virtual endoscopy with variation of reconstruction threshold allows the detection of small labyrinthine fistulas with diameters of 0.3 mm or smaller.
Author Affiliations: Radiology Department, Clinique Turin (Dr Bensimon), Equipe Mixte INSERM-Universite 0112, Faculté Xavier Bichat, Université Paris 7 (Drs Grayeli, Ferrary, and Sterkers), and Centre d’Explorations Oto-neurologiques (Dr Toupet), Paris, France; and Otolaryngology Department, Hôpital Beaujon, Assistance Publique-Hopitaux Paris, Clichy, France (Drs Grayeli, Ferrary, and Sterkers).
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