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Juan Pablo Rodrigo, MD; Juana María García-Pedrero, PhD; María Victoria González, PhD; María Pilar Fernández, PhD; Carlos Suárez, MD; Agustín Herrero, MD

Arch Otolaryngol Head Neck Surg. 2004;130:211-215.

Objective  To examine the expression pattern of annexin A1 in normal and chronically inflamed nasal mucosa to investigate its possible role in nasal inflammation.

Design  Immunohistochemical analysis.

Subjects  Samples of middle turbinates from 5 healthy subjects and 5 patients with perennial rhinitis, and samples of nasal polyps from 7 patients.

Interventions  Annexin A1 expression was examined with a standard immunohistochemical protocol on paraffin-embedded sections.

Results  Annexin A1 was highly expressed by ciliated cells, where it was concentrated on the apical surface and within the cilia. Goblet cells and nondifferentiated basal epithelial cells did not stain. In the glands of the lamina propria, intense staining was found in the cytoplasm and in the nuclei of the cells in the duct epithelium, whereas acinar cells did not stain. Intense cytoplasmic staining was observed in infiltrating polymorphonuclear cells and macrophages. No differences in the pattern or the level of expression of annexin A1 were found in the epithelial cells and glands of normal and chronically inflamed (perennial rhinitis or polyps) nasal mucosa.

Conclusion  These results suggest that the expression of annexin A1 in respiratory epithelium of nasal mucosa is related to cell type and differentiation status of the cells and is not significantly altered by inflammatory diseases.

From the Departments of Otolaryngology (Drs Rodrigo, García-Pedrero, González, and Suárez) and Pathology (Dr Herrero), Hospital Central Universitario de Asturias, Instituto Universitario de Oncología; and the Department of Biochemistry and Molecular Biology, Universidad de Oviedo, (Dr Fernández), Oviedo, Spain. The authors have no relevant financial interest in this article.

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