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The Significance of Serum Soluble Intercellular Adhesion Molecule 1 and Transforming Growth Factor  in Patients With Nasopharyngeal Carcinoma
Yongqiang Yu, MD;
Weidong Dong, MD;
Xiaorong Zhou, BN;
Shuhua Li, MD
Arch Otolaryngol Head Neck Surg. 2004;130:1205-1208.
Objective To determine serum levels of soluble intercellular adhesion molecule 1 (sICAM-1) and transforming growth factor  (TGF-) in 51 patients with nasopharyngeal carcinoma before, during, and after radiation therapy (5-year follow-up period).
Results The mean ± SD serum levels of the 2 cytokines were found to be higher in patients before radiotherapy (sICAM-1, 369.6 ± 123.7 ng/mL; TGF-, 36.6 ± 24.6 ng/mL) than after radiotherapy (sICAM-1, 225.9 ± 124.3 ng/mL; TGF-, 20.2 ± 22.3 ng/mL) (P<.05), and they were significantly higher in patients with recurrence (sICAM-1, 512.5 ± 271.2 ng/mL; TGF-, 48.2 ± 23.4 ng/mL) and in those who died (sICAM-1, 542.6 ± 245.4 ng/mL; TGF-, 50.2 ± 28.8 ng/mL) than in patients with no recurrence (sICAM-1, 217.9 ± 116.4 ng/mL; TGF-d, 21.5 ± 26.8 ng/mL) and in those who survived (sICAM-1, 209.4 ± 167.2 ng/mL; TGF-, 20.4 ± 27.3 ng/mL) (P<.05). The increases in serum levels occurred approximately 3 months before relapse.
Conclusion We found that sICAM-1 and TGF- levels are extremely useful markers for predicting illness, recurrence, and survival.
From the Department of Otolaryngology, Beifang Hospital of Shenyang, Shenyang, China. The authors have no relevant financial interest in this article.
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