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Three-Dose vs Extended-Course Clindamycin Prophylaxis for Free-Flap Reconstruction of the Head and Neck
William R. Carroll, MD;
David Rosenstiel, MD;
Jobe R. Fix, MD;
Jorge de la Torre, MD;
Joel S. Solomon, MD;
Brian Brodish, MD;
Eben L. Rosenthal, MD;
Tad Heinz, MD;
Santosh Niwas, PhD;
Glenn E. Peters, MD
Arch Otolaryngol Head Neck Surg. 2003;129:771-774.
Background Twenty-four hours of perioperative antibiotics provides effective prophylaxis for most head and neck cancer resections. Many reconstructive surgeons have been hesitant to apply this standard to free-flap reconstruction of the head and neck. This prospective clinical trial compared short-course and long-course clindamycin prophylaxis for wound infection in patients with head and neck cancer undergoing free-flap reconstruction.
Methods Seventy-four patients were randomized to receive short-course (3 doses) or long-course (15 doses) clindamycin perioperatively. Wound infections, fistulas, and other postoperative complications were documented by faculty surgeons who were blinded as to treatment group.
Results The differences in wound infections and other complications were statistically insignificant. No other independent predictors of wound complications emerged in this series of patients.
Conclusions Short-course clindamycin is as effective as long-course clindamycin in preventing wound infections after free-flap surgery for head and neck ablative defects.
From the Divisions of Otolaryngology–Head and Neck Surgery (Drs Carroll, Rosenstiel, Brodish, Rosenthal, and Peters) and Plastic Surgery (Drs Fix, de la Torre, Solomon, and Heinz) and Comprehensive Cancer Center Biostatistics Unit (Dr Niwas), University of Alabama at Birmingham. Dr Heinz is now in private practice in Colorado Springs, Colo. The authors have no relevant financial interest in this article.
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