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Desiderio Passàli, MD, PhD; Joel M. Bernstein, MD, PhD; Francesco Maria Passàli, MD; Valerio Damiani, MD; Giulio Cesare Passàli, MD; Luisa Bellussi, MD, ChD

Arch Otolaryngol Head Neck Surg. 2003;129:656-659.

Objective  To demonstrate the long-term efficacy of intranasal furosemide, an inhibitor of the sodium chloride cotransporter channel at the basolateral surface of the respiratory epithelial cell, vs no therapeutic intervention vs intranasal mometasone furoate, a corticosteroid, in preventing relapses of chronic hyperplastic sinusitis with nasal polyposis.

Design  Randomized prospective controlled study. Patients were examined every 6 months during follow-up (range, 1-9 years).

Patients  One hundred seventy patients with bilateral obstructive or minimally obstructive chronic hyperplastic sinusitis with nasal polyposis.

Intervention  All patients were surgically treated in the ENT Department, University of Siena Medical School. One month after surgery, group 1 patients (n = 97) started treatment with intranasal furosemide, group 2 (n = 40) received no therapeutic treatment, and group 3 (n = 33) were treated with mometasone.

Main Outcome Measures  Clinical and instrumental evaluation of postoperative outcomes.

Results  Seventeen (17.5%) of 97 patients in group 1, 12 (30.0%) of 40 patients in group 2, and 8 (24.2%) of 33 patients in group 3 experienced nasal polyposis relapses. We noted a prevalence of early-stage relapse in patients treated with furosemide or mometasone, whereas patients who did not receive any treatment experienced more severe grades of chronic hyperplastic sinusitis with nasal polyposis (P<.005).

Conclusion  Use of intranasal furosemide represents a valid therapeutic treatment in the prevention of chronic hyperplastic sinusitis with nasal polyposis.

From the ENT Department, University of Siena Medical School, Siena, Italy (Drs D. Passàli, F. M. Passàli, Damiani, G. C. Passàli, and Bellussi); and Departments of Otolaryngology and Pediatrics, State University of New York at Buffalo (Dr Bernstein). The authors have no relevant financial interest in this article.

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