This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (16)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Genetics  • Genetic Counseling/ Testing/ Therapy  • Genetics of Head & Neck Disease  • Paranasal Sinus Disease  • Pathology of Head & Neck  • Alert me on articles by topic

Meltem Yalinay Cirak, MD; Ali Ozdek, MD; Dicle Yilmaz, MD; Unal Bayiz, MD; Erdal Samim, MD; Sevgi Turet, PhD

Arch Otolaryngol Head Neck Surg. 2003;129:1225-1229.

Objective  To determine the presence of Helicobacter pylori and, if detected, the prevalence of the CagA gene in adenotonsillectomy specimens by polymerase chain reaction (PCR).

Design  A prospective clinical trial.

Setting  Tertiary referral center.

Patients and Methods  The study population comprised 23 patients who had undergone adenoidectomy, tonsillectomy, or adenotonsillectomy under local or general anesthesia. Helicobacter pylori DNA was extracted from 3-mm-diameter tissue samples obtained from each tonsil and adenoid tissue specimens. The amplifications were performed for the 16S ribosomal RNA (rRNA) and CagA genes of H pylori in the samples of which H pylori DNA was detected.

Results  In examining all the samples, 7 (30%) of 23 patients were shown to be positive for H pylori DNA, 5 (71%) of whom also possessed the CagA gene.

Conclusions  Tonsil and adenoid tissues may be an ecological niche of the mouth without regard to transient or permanent colonization. Oral-oral transmission may be a possible mode of spread of H pylori.

From the School of Medicine, Department of Microbiology and Clinical Microbiology, Gazi University (Drs Cirak, Yilmaz, and Turet), and Ankara Research and Training Hospital, Department of Otorhinolaryngology, Ministry of Health (Drs Ozdek, Bayiz, and Samim), Ankara, Turkey. The authors have no relevant financial interest in this article.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Helicobacter pylori Detection and Antimicrobial Susceptibility Testing
Megraud and Lehours
Clin. Microbiol. Rev. 2007;20:280-322.
ABSTRACT | FULL TEXT  

Prevalence of Helicobacter pylori DNA in Recurrent Aphthous Ulcerations in Mucosa-Associated Lymphoid Tissues of the Pharynx
Elsheikh and Mahfouz
Arch Otolaryngol Head Neck Surg 2005;131:804-808.
ABSTRACT | FULL TEXT  

Helicobacter pylori in Children Who Are Prone to Upper Respiratory Tract Infections
Pitkaranta et al.
Arch Otolaryngol Head Neck Surg 2005;131:256-258.
ABSTRACT | FULL TEXT