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Meltem Yalinay Cirak, MD; Ali Ozdek, MD; Dicle Yilmaz, MD; Unal Bayiz, MD; Erdal Samim, MD; Sevgi Turet, PhD

Arch Otolaryngol Head Neck Surg. 2003;129:1225-1229.

Objective  To determine the presence of Helicobacter pylori and, if detected, the prevalence of the CagA gene in adenotonsillectomy specimens by polymerase chain reaction (PCR).

Design  A prospective clinical trial.

Setting  Tertiary referral center.

Patients and Methods  The study population comprised 23 patients who had undergone adenoidectomy, tonsillectomy, or adenotonsillectomy under local or general anesthesia. Helicobacter pylori DNA was extracted from 3-mm-diameter tissue samples obtained from each tonsil and adenoid tissue specimens. The amplifications were performed for the 16S ribosomal RNA (rRNA) and CagA genes of H pylori in the samples of which H pylori DNA was detected.

Results  In examining all the samples, 7 (30%) of 23 patients were shown to be positive for H pylori DNA, 5 (71%) of whom also possessed the CagA gene.

Conclusions  Tonsil and adenoid tissues may be an ecological niche of the mouth without regard to transient or permanent colonization. Oral-oral transmission may be a possible mode of spread of H pylori.

From the School of Medicine, Department of Microbiology and Clinical Microbiology, Gazi University (Drs Cirak, Yilmaz, and Turet), and Ankara Research and Training Hospital, Department of Otorhinolaryngology, Ministry of Health (Drs Ozdek, Bayiz, and Samim), Ankara, Turkey. The authors have no relevant financial interest in this article.

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