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Lucie Gregoire, PhD; Patrick M. Reidy, MD; Raja Rabah, MD; Wayne D. Lancaster, PhD

Arch Otolaryngol Head Neck Surg. 2003;129:1221-1224.

Objective  To determine HLA-DQ and -DQ1 allele associations in juvenile-onset recurrent respiratory papillomatosis (RRP) for risk, disease course, and human papillomavirus type.

Design  A nonrandomized controlled study was performed on DNA extracted from papilloma specimens of children with a history of RRP, and from peripheral blood of African American and white children without RRP. The frequencies of DQ and DQ1 alleles were compared between patients and ethnically matched controls.

Subjects  Records of 48 children treated for RRP at Children's Hospital of Michigan in Detroit (26 African American and 22 white) were reviewed. Control subjects consisted of 80 African American and 80 white children seen at the hospital for conditions other than RRP.

Results  African American and white patients with DQ1*050X (not *0501, *0502, *0503, *0504, or *0505) were at higher risk to develop RRP than controls (P = .01 and .03, respectively). DQ1*0402 was protective for African Americans (P = .01). Whites with DQ*0102 were at risk for RRP (P = .03). This allele was associated with disease remission in African Americans (P = .03). DQ*0101/0104 conferred protection in whites (P = .047). No association was seen for allele frequency and human papillomavirus type. Whites with haplotype DQ*0501/DQ1*0201 were at high risk for RRP (P = .002). No relationships were seen for African Americans or whites between haplotype frequencies and disease course or human papillomavirus type.

Conclusions  HLA-DQ and -DQ1 alleles occur at different frequencies in African American and white children with RRP than controls. Specific alleles influence risk for RRP. Allele and haplotype frequencies have some influence on disease course, but were independent of human papillomavirus type.

From the Departments of Immunology and Microbiology (Dr Gregoire), Otolaryngology (Dr Reidy), and Pathology (Dr Rabah) and Center for Molecular Medicine and Genetics (Dr Lancaster), Wayne State University School of Medicine, Detroit, Mich. The authors have no relevant financial interest in this article.

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