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Evaluation of Topical Povidone-Iodine in Chronic Suppurative Otitis Media
C. Jaya, MBBS, MS;
Anand Job, MBBS, DLO, MS;
Elizabeth Mathai, MBBS, MD, DTM&H, MSc;
B. Antonisamy, MSc, PhD
Arch Otolaryngol Head Neck Surg. 2003;129:1098-1100.
Objectives To evaluate if povidone-iodine (PVP-I) can be used topically in the treatment of chronic suppurative otitis media–tubotympanic disease and to compare it with ciprofloxacin hydrochloride ear drops.
Design Prospective double-blind randomized study.
Setting Academic tertiary medical center.
Patients Forty patients with chronic suppurative otitis media were randomized into 2 groups.
Intervention One group (19 patients) received 5% PVP-I ear drops, while the other group (21 patients) received 0.3% ciprofloxacin ear drops. Both were administered topically, 3 drops 3 times daily for 10 days. These patients were followed up at weekly intervals for up to 4 weeks after commencing therapy.
Results Clinical improvement at the end of study was 88% in the PVP-I group and 90% in the ciprofloxacin group. The most commonly isolated organism was Pseudomonas aeruginosa. In vitro resistance to ciprofloxacin was seen in 17% of organisms, while no resistance was seen for PVP-I.
Conclusions To our knowledge, this is the first study to evaluate the efficacy of PVP-I as a topical agent in the treatment of chronic suppurative otitis media. The results show that clinically, topical PVP-I is as effective as topical ciprofloxacin, with a superior advantage of having no in vitro drug resistance. Also, there is an added benefit of reduced cost of therapy.
From the Departments of Otorhinolaryngology and Head and Neck Surgery (Drs Jaya and Job), Clinical Microbiology (Dr Mathai), and Biostatistics (Dr Antonisamy), Christian Medical College, Vellore, India. The authors have no relevant financial interest in this article.
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