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Postoperative Hemorrhage With Nonsteroidal Anti-inflammatory Drug Use After Tonsillectomy
A Meta-analysis
Srinivasan Krishna, MD;
Larry F. Hughes, PhD;
Sandra Y. Lin, MD
Arch Otolaryngol Head Neck Surg. 2003;129:1086-1089.
Objective To use standard meta-analysis techniques to determine the risk of postoperative hemorrhage associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) after tonsillectomy.
Data Sources The MEDLINE database (1966-2001) restricted to the English language was searched using the keywords tonsillectomy, hemorrhage, analgesics, and NSAID in various combinations. Additionally, published articles were cross-referenced. To ensure completeness, the search was rerun using the Science Citation Index database.
Study Selection Of the 110 articles identified, 7 were selected. Selected studies were prospective trials comparing the effects of an NSAID and a control drug on posttonsillectomy pain and hemorrhage in pediatric and/or adult patients. In all cases, the NSAID or control was administered through an enteric route in the postoperative period. Patients were monitored for early and delayed hemorrhage.
Data Extraction Data were extracted independently by 2 investigators.
Data Synthesis A random effects model was used to compute a pooled odds ratio. For the 1368 patients included in analysis, the pooled odds ratio of posttonsillectomy hemorrhage with NSAIDs compared with controls was 1.29 and was not statistically significant (95% confidence interval, 0.85-1.73; P .05). A subgroup analysis revealed an odds ratio of 0.93 (95% confidence interval, 0.44 -1.95; P.05) for the nonaspirin NSAID group, while the aspirin group had a statistically significant odds ratio of 1.94 (95% confidence interval, 1.09-3.42; P = .02).
Conclusions There is an increased risk of posttonsillectomy hemorrhage with the use of aspirin after tonsillectomy; however, there appears to be no significant increased risk of bleeding for nonaspirin NSAIDs in this meta-analysis.
From the Division of Otolaryngology–Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield (Drs Krishna and Hughes); and Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Md (Dr Lin). The authors have no relevant financial interest in this article.
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