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Clear Cell Odontogenic Carcinoma
Report of a Case and Analysis of the Literature
Margaret Brandwein, MD;
Nasser Said-Al-Naief, DDS, MS;
Ron Gordon, PhD;
Mark Urken, MD
Arch Otolaryngol Head Neck Surg. 2002;128:1089-1095.
Background Clear cell odontogenic carcinoma (CCOC), which has been described within
the past 2 decades, is a rare odontogenic tumor that tends to occur in the
mandible of older adults, with a predilection for women. It is potentially
aggressive and capable of multiple local recurrences and locoregional and
distant metastases.
Objectives To report the clinicopathologic findings and follow-up of a case of
CCOC and to review the literature.
Design Case report and literature review.
Main Outcome Measurements Findings from histologic analysis, immunohistochemistry, and electron
microscopy.
Results An 81-year-old woman experienced 3 locoregional recurrences within 21
months of initial therapy. She is presently disease free, 4.5 years after
initial resection, having received multiple resections and adjuvant radiotherapy.
Conclusions The diagnosis of CCOC must be considered in the differential diagnosis
of jaw tumors with a clear cell component. For these tumors, resection with
negative margins is the treatment of choice because more conservative surgery
(eg, curettage) inevitably results in recurrence and/or metastasis. Adjuvant
radiotherapy is a rational option for tumors that have eroded cortex.
From the Departments of Pathology (Drs Brandwein, Said-Al-Naief, and
Gordon) and Otolaryngology (Drs Brandwein and Urken), Mount Sinai Medical
Center, New York, NY. Dr Said-Al-Naief is currently at the Department of Pathology,
University of Alabama, Birmingham.
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