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Long-term Survival Outcome in Transhyoid Resection of Base of Tongue Squamous Cell Carcinoma
Babak Azizzadeh, MD;
Pedram Enayati, BS;
Dinesh Chhetri, MD;
Ellie Maghami, MD;
Babak Larian, MD;
Keith E. Blackwell, MD;
Elliot Abemayor, MD, PhD;
Thomas C. Calcaterra, MD
Arch Otolaryngol Head Neck Surg. 2002;128:1067-1070.
Background The transhyoid approach for the resection of squamous cell carcinoma
(SCC) of the base of the tongue continues to evolve and remains controversial.
We previously reported that the functional outcome of this operation is superior
to that of the traditional transmandibular approaches.
Objective To report our long-term survival rates for T1, T2, and select T3 SCCs
of the base of the tongue using the transhyoid approach.
Patients and Methods Twenty-eight patients with SCC of the base of the tongue were treated
using a transhyoid approach at the University of California, Los Angeles,
Medical Center between 1981 and 1998.
Results All 28 patients underwent simultaneous neck dissection, and 27 patients
underwent postoperative radiation therapy. The majority of the patients had
advanced stage III or IV SCC. Twenty-five of the 28 patients had clear margins
in the final pathologic specimen. The overall 3- and 5-year patient survival
rates were 88.5% and 80.0%, respectively. Tumor-specific 5-year survival rates
were 80.0%, 84.6%, and 50.0% for T1, T2, and T3 tumors, respectively. Stage-specific
5-year survival rates were 60.0%, 100.0%, and 80.0% for stages II, III, and
IV, respectively.
Conclusions The advantages of the transhyoid approach to SCC of the base of the
tongue in conjunction with neck dissection and postoperative radiation therapy
include excellent long-term patient survival, improved swallowing and speech
function, outstanding tumor exposure, and minimal cosmetic deformity.
From the Division of Head and Neck Surgery, UCLA School of Medicine,
Los Angeles, Calif.
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