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Aaron D. Friedman, BA; Jay B. Shah, BA; Thomas G. Takoudes, MD; Joseph Haddad, Jr, MD

Arch Otolaryngol Head Neck Surg. 2002;128:1055-1057.

Objective  To determine whether there is an increased amount of free radical–mediated damage in diseased vs healthy tissue from patients with chronic rhinosinusitis.

Design  Pathophysiologic study. Samples of heathly and diseased tissue were taken from each patient. Lipid peroxides (LPOs) are a by-product of free radical–mediated damage; LPO levels and LPO/protein ratios were determined for each patient.

Subjects  Consecutive series of 13 human subjects undergoing functional endoscopic sinus surgery to treat chronic rhinosinusitis.

Results  The mean LPO/protein ratio for healthy tissue was 3.52 x 10^-5, while that for the diseased tissue was 3.49 x 10^-5. There was no statistically significant difference in the LPO/protein ratio between healthy and diseased tissue (95% confidence interval, -3.00 x 10^-5 to 2.94 x 10^-5).

Conclusion  Free radical–induced damage, if present, was the same in infected and control tissues in this pilot investigation into the pathophysiologic characteristics of human chronic rhinosinusitis.

From the Department of Otolaryngology–Head and Neck Surgery, New York Presbyterian Hospital and College of Physicians and Surgeons, Columbia University, New York.

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