 |
|
Nodal Metastasis in Major Salivary Gland Cancer
Predictive Factors and Effects on Survival
Neil Bhattacharyya, MD;
Marvin P. Fried, MD
Arch Otolaryngol Head Neck Surg. 2002;128:904-908.
Objectives To determine how regional nodal metastasis affects survival in patients
with major salivary gland malignancy and to identify clinical predictors for
nodal disease.
Methods Major salivary gland cancer cases with nodal sampling were identified
from the Surveillance, Epidemiology, and End Results cancer database for 1988
through 1998. Kaplan-Meier survival analysis was conducted to compare patients
with and without histopathologic evidence of nodal disease. Multivariate logistic
regression analysis was used to determine the influence of clinical predictors
on the presence of regional nodal disease.
Results A total of 1268 patients with major salivary gland malignancy and regional
node sampling were identified. Mean age at diagnosis was 58.3 years, with
a male-female ratio of 1:4. Mean tumor size was 3.0 cm. Overall mean survival
time was 83 months (95% confidence interval, 80-87 months). Patients with
no evidence of nodal cancer had significantly improved survival over patients
with any pathologically positive nodes (mean survival time, 100 months vs
59 months, respectively; P<.001). Patient age,
tumor histopathologic type, facial nerve involvement, extraglandular involvement,
tumor grade, and tumor size were significant clinical predictors of nodal
disease. Facial nerve involvement, tumor grade, and squamous cell carcinoma
subtype exhibited the highest increased odds ratios for nodal metastasis.
Conclusions Nodal disease significantly decreases survival in patients with major
salivary gland malignancy. Tumor histopathologic type, facial nerve involvement,
extraglandular tumor extension, and tumor grade are the most important predictors
of nodal disease.
From the Division of Otolaryngology, Brigham & Women's Hospital,
Harvard Medical School, Boston, Mass (Dr Bhattacharyya); and Department of
Otolaryngology, Montefiore Medical Center, Albert Einstein College of Medicine,
New York, NY (Dr Fried).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Survival Rates of Sinonasal Squamous Cell Carcinoma With the New AJCC Staging System
Lee et al.
Arch Otolaryngol Head Neck Surg 2007;133:131-134.
ABSTRACT
| FULL TEXT
Surgical Treatment of Cervical Nodal Metastases in Patients With Papillary Thyroid Carcinoma
Bhattacharyya
Arch Otolaryngol Head Neck Surg 2003;129:1101-1104.
ABSTRACT
| FULL TEXT
Survival and Staging Characteristics for Non-Squamous Cell Malignancies of the Maxillary Sinus
Bhattacharyya
Arch Otolaryngol Head Neck Surg 2003;129:334-337.
ABSTRACT
| FULL TEXT
Survival and Prognosis in Hurthle Cell Carcinoma of the Thyroid Gland
Bhattacharyya
Arch Otolaryngol Head Neck Surg 2003;129:207-210.
ABSTRACT
| FULL TEXT
|
