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Andreas F. P. Temmel, MD; Christian Quint, MD; Bettina Schickinger-Fischer, MD; Ludger Klimek, MD; Elisabeth Stoller; Thomas Hummel, MD

Arch Otolaryngol Head Neck Surg. 2002;128:635-641.

Objective  To investigate the consequences of olfactory loss and explore specific questions related to the effect of duration of olfactory loss, degree of olfactory sensitivity, and cause of the olfactory loss.

Patients  A total of 278 consecutive patients with hyposmia or anosmia were examined.

Results  Causes of olfactory loss were categorized as follows: trauma (17%), upper respiratory tract infection (URI) (39%), sinonasal disease (21%), congenital anosmia (3%), idiopathic causes (18%), or other causes (3%). Our data suggest that (1) recovery rate was higher in URI olfactory loss than in olfactory loss from other causes; (2) likelihood of recovery seemed to decrease with increased duration of olfactory loss; and (3) the elderly are more prone to URI olfactory loss than younger patients. Regarding changes in quality of life (QoL), we found that (1) in most patients olfactory loss caused food-related problems; (2) loss in QoL did not change with duration of olfactory loss; (3) younger patients had more complaints than older ones, and women had more complaints than men; (4) complaint scores were higher in hyposmic patients than in anosmic patients; and (5) self-rated depression did not relate to measured olfactory function.

Conclusions  Among many complaints of olfactory loss, the predominant ones were food related. This loss in QoL seemed to be of greater importance in younger than in older people, and women seem to be affected more strongly than men.

From the Department of Otorhinolaryngology, University of Vienna, Austria (Drs Temmel, Quint, and Schickinger-Fischer); Deutsche Klinik für Diagnostik, Wiesbaden (Dr Klimek), and the Department of Otorhinolaryngology, University of Dresden Medical School, Dresden (Ms Stoller and Dr Hummel), Germany.

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