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The Role of Mitomycin in the Prevention and Treatment of Scar Formation in the Pediatric Aerodigestive Tract
Friend or Foe?
Reza Rahbar, DMD, MD;
Dwight T. Jones, MD;
Roger C. Nuss, MD;
David W. Roberson, MD;
Margaret A. Kenna, MD;
Trevor J. McGill, MD;
Gerald B. Healy, MD
Arch Otolaryngol Head Neck Surg. 2002;128:401-406.
Objective To evaluate the role of mitomycin in the prevention and treatment of
scar formation in the pediatric aerodigestive tract.
Design Prospective study; institutional review board–approved clinical
trial.
Setting Tertiary care pediatric medical center.
Patients Fifteen patients; choanal atresia in 5 patients, airway stenosis in
8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis
in 1 patient.
Outcome The efficacy and safety of mitomycin in the prevention of scar formation.
Intervention All patients underwent surgical repair of the stenotic area, followed
by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes.
Results Ten patients (67%) showed major improvement, 4 patients (27%) showed
minor improvement, and 1 patient (7%) showed no improvement.
Conclusion Topical application of mitomycin can play an effective role in the prevention
and treatment of scar formation in the aerodigestive tract.
From the Department of Otolaryngology and Communication Disorders,
Children's Hospital Boston, and Department of Otology and Laryngology, Harvard
Medical School, Boston, Mass.
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