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Is Corticosteroid Therapy Effective for Sudden-Onset Sensorineural Hearing Loss at Lower Frequencies?
Shin-ichiro Kitajiri, MD;
Keisaku Tabuchi, MD;
Harukazu Hiraumi, MD;
Tomoko Hirose, MD
Arch Otolaryngol Head Neck Surg. 2002;128:365-367.
Objective To assess the efficacy of corticosteroid therapy for sudden-onset sensorineural
hearing loss at lower frequencies.
Design Retrospective, nonrandomized, controlled study.
Patients and Methods The recovery rate, recovery/improvement rate, and period between the
start of therapy and improvement of symptoms were studied in 2 groups: the
control group, consisting of 36 patients treated with adenosine triphosphate
disodium, kallidinogenase, and cyanocobalamin between March 1, 2000, and January
31, 2001; and the corticosteroid-treated group, consisting of 42 patients
treated with corticosteroids in addition to the previously mentioned drugs
between April 1, 1997, and February 29, 2000.
Results No significant difference (P = .83) was noted
in the recovery rate between the control group (81%) and the corticosteroid-treated
group (79%), and the recovery/improvement rate was the same for the 2 groups
(83%). In addition, there was no significant difference (P = .84) for the mean ± SD period between the start of therapy
and improvement of symptoms between the control group (3.9 ± 2.7 days)
and the corticosteroid-treated group (3.7 ± 2.1 days).
Conclusion Corticosteroids were not effective for sudden-onset sensorineural hearing
loss at lower frequencies.
From the Department of Otolaryngology–Head and Neck Surgery,
Kyoto University Graduate School of Medicine, Kyoto (Dr Kitajiri); the Tabuchi
ENT Clinic, Kobe City, Hyogo (Dr Tabuchi); and the Department of Otolaryngology,
Toyooka Hospital, Toyooka City, Hyogo (Drs Hiraumi and Hirose), Japan.
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