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Snehal G. Patel, MD; Daniel G. Coit, MD; Ashok R. Shaha, MD; Mary Sue Brady, MD; Jay O. Boyle, MD; Bhuvanesh Singh, MD; Jatin P. Shah, MD; Dennis H. Kraus, MD

Arch Otolaryngol Head Neck Surg. 2002;128:285-291.

Objective  To report the results of sentinel lymph node biopsy (SLNB) for cutaneous head and neck melanomas (CMHNs).

Design  Consecutive series followed for a median of 20 months.

Setting  Tertiary cancer care center.

Patients  Fifty-six individuals with clinically node-negative CMHN, median Breslow thickness, 2.6 mm (range, 0.2-20.0 mm).

Interventions  Preoperative technetium 99m sulfur colloid lymphoscintigraphy (PLSG) followed within 4 hours by intraoperative handheld gamma probe localization (IHGP). Intraoperative injection of 1% isosulfan blue dye (IBD) was used in 48 patients. Immediate completion nodal dissection was performed for metastatic SLNs on intraoperative frozen section analysis and monitoring for negative SLNs.

Main Outcome Measures  Rate of SLN identification, SLN and non-SLN positivity, same-basin recurrence, and disease-specific and recurrence-free survival.

Results  Combination of IHGP and IBD improved SLN identification to 96% from 93% for IHGP and 73% for IBD alone. Four patients had a positive SLN on frozen section analysis. A negative SLNB correctly predicted regional nodal control in 47 of 48 patients but missed 1 of 5 patients who had regional lymphatic disease. All 4 patients who failed SLNB remain alive and free of recurrent disease. Two-year Kaplan-Meier disease-specific and relapse-free survival was 91% and 88%, respectively. Two-year disease-specific survival was 93% for SLN-negative patients and 50% for SLN-positive patients (P= .20).

Conclusions  Combining PLSG with IHGP and IBD improves the success rate of SLNB. Although SLNB is a reliable indicator of the status of the draining lymphatic basins in CMHN, patients with negative SLNs must be observed for longer periods to understand the true implications of the procedure.

From the Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY.

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