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Clinicopathological and Immunohistochemical Features of 60 Cases in Brazil

Fàbio A. Alves, DDS,PhD; Daniel E. C. Perez, DDS; Osley P. Almeida, DDS,PhD; Márcio A. Lopes, DDS,PhD; Luiz P. Kowalski, MD,PhD

Arch Otolaryngol Head Neck Surg. 2002;128:1400-1403.

The submandibular gland is involved in only 5% to 10% of the salivary gland tumors, and pleomorphic adenoma (PA) is the most common tumor affecting it. This study describes the clinicopathological features and immunohistochemical expression of Ki-67 and p53 in 60 cases of submandibular salivary gland PAs. Most of the patients were in the third and fifth decades of life and 37 (62%) of them were women. Tumor sizes varied from 1 to 10 cm and the mean time between symptom onset and treatment was 52 months. Only 1 patient experienced local recurrence, 3 years after treatment. Histologically, most tumors consisted chiefly in a chondromyxoid stroma. Stroma-rich PAs were larger than stroma-poor ones (P<.02). All PAs were found negative for Ki-67 and p53. These results show that PAs of the submandibular gland are histologically similar to PAs of other salivary glands, and that they have a low proliferative rate and a good prognosis.

From the Departments of Oral Pathology and Semiology, School of Dentistry of Piracicaba, University of Campinas-UNICAMP (Drs Alves, Perez, Almeida, and Lopes), and Head and Neck Surgery and Otorhinolaryngology, Cancer Hospital AC Camargo (Dr Kowalski), São Paulo, Brazil.

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