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Salvage Surgery for Recurrent Nasopharyngeal Carcinoma
Sheng-Po Hao, MD;
Ngan-Ming Tsang, MD, DSc;
Chen-Nen Chang, MD
Arch Otolaryngol Head Neck Surg. 2002;128:63-67.
Objective To evaluate the results of salvage surgery for patients with primary
recurrence of nasopharyngeal carcinoma after radiotherapy.
Design Cohort study.
Setting Academic tertiary referral center.
Patients Eighteen consecutive patients with primary recurrence of nasopharyngeal
carcinoma after radiation failure underwent nasopharyngectomy for cure via
a facial translocation approach from July 1, 1993, to December 31, 1999. Follow-up
ranged from 3 to 71 months. Five patients with skull base invasion required
a combined neurosurgical approach to treatment. Seven patients had additional
postoperative radiotherapy.
Results The actuarial 3-year survival was 57%, while the local control was 78%.
Four of 5 patients who had skull base invasion achieved local control. There
was no surgical mortality, and the morbidity was 22%.
Conclusion Advances in skull base surgery make possible the effective control of
primary recurrence of nasopharyngeal carcinoma, with acceptable mortality
and morbidity.
From the Departments of Otolaryngology (Dr Hao), Radiation Oncology
(Dr Tsang), and Neurosurgery (Dr Chang), and Head & Neck Oncology (II)
(Drs Hao and Tsang), Chang Gung Memorial Hospital, Chang Gung University,
Taoyua, Taiwan, Republic of China.
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