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William R. Wilson, MD; Robert S. Siegel, MD; Leonidas A. Harisiadis, MD; David O. Davis, MD; Hoang H. Nguyen, MPH; William O. Bank, MD

Arch Otolaryngol Head Neck Surg. 2001;127:809-812.

Objective  To assess the effectiveness of a protocol consisting of 4 cycles of high-dose intra-arterial cisplatin infusions followed by radiation therapy for improving chemotherapy response rates, organ preservation, and survival in patients with advanced-stage untreated and previously treated squamous cell carcinoma of the head and neck.

Design and Setting  A prospective study of sequentially enrolled patients treated in an academic medical center. The Kaplan-Meier method was used for survival analysis.

Patients  Fifty-eight nonpregnant adults, 18 years of age or older, with measurable untreated or recurrent advanced biopsy-proven squamous cell carcinoma of the head and neck.

Main Outcome Measures  Response rate to targeted intra-arterial cisplatin infusions, organ preservation, and survival.

Results  Fifty-eight patients (44 men and 14 women) were followed up for at least 2 years (median duration of follow-up, 27 months). Twenty-nine (67%) of the 43 previously untreated patients had a complete response to intra-arterial cisplatin therapy. Of the untreated patients, 28 are alive and disease free after a median follow-up time of 30 months. Five of the patients with recurrent disease had a complete response to intra-arterial cisplatin therapy. There were 4 survivors after a median follow-up time of 17.5 months. Of note, there were no deaths or serious complications related to the treatment in either group.

Conclusions  High-dose intra-arterial cisplatin therapy provides a high complete and partial response rate (91%). The combination of high-dose intra-arterial cisplatin and radiation therapy is effective in improving survival and organ preservation rates in patients with previously untreated, advanced squamous cell carcinoma of the head and neck. This treatment protocol is much less effective for recurrent disease.

From the Divisions of Otolaryngology (Dr Wilson), Hematology and Oncology (Dr Siegel and Mr Nguyen), Radiation Oncology (Dr Harisiadis), Radiology (Dr Davis), and Interventional Neuroradiology (Dr Bank), George Washington University Medical Center, and the Washington Hospital Center, Washington, DC.

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