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Takaki Miwa, MD, PhD; Mitsuru Furukawa, MD, PhD; Toshiaki Tsukatani, MD, PhD; Richard M. Costanzo, PhD; Laurence J. DiNardo, MD; Evan R. Reiter, MD

Arch Otolaryngol Head Neck Surg. 2001;127:497-503.

Objective  To determine whether olfactory loss affects patients' quality of life or level of disability.

Design  Retrospective survey using questionnaire data and clinic database review.

Setting  Two university medical center smell and taste clinics.

Patients  A total of 1407 patients were tested for smell and taste disturbances from 1984 through 1998. Surveys were mailed to 1093 patients who had abnormal test scores; 420 (38.4%) returned completed surveys. Patients were grouped by self-rated ability to smell as "impaired" (those reporting persisting deficits) or "improved" (those reporting no smell problem when surveyed).

Main Outcome Measures  Response frequencies were compared between the 2 groups for questions regarding ability to perform common activities of daily living and quality-of-life issues.

Results  Mean (±SD) number of activities of daily living affected by olfactory loss was 4.70 ± 3.56 for the impaired group and 0.61 ± 1.58 for the improved group (P<.001). Among specific activities, the most common cited impairments were ability to detect spoiled food (impaired vs improved groups, 75% vs 12%; P<.001), gas leaks (61% vs 8%; P<.001), or smoke (50% vs 1%; P<.001); eating (53% vs 12%; P<.001); and cooking (49% vs 12%; P<.001). Differences in quality-of-life issues were reported primarily in the areas of safety and eating. Overall satisfaction with life was reported by 87% of the improved group but only 50% of the impaired group (P<.001).

Conclusions  Patients reporting persistent olfactory impairment after previously documented olfactory loss indicate a higher level of disability and lower quality of life than those with perceived resolution of olfactory compromise.

From the Department of Otorhinolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan (Drs Miwa, Furukawa, and Tsukatani), and Department of Otolaryngology–Head and Neck Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond (Drs Costanzo, DiNardo, and Reiter).

Corresponding author and reprints: Evan R. Reiter, MD, Department of Otolaryngology–Head and Neck Surgery, PO Box 980146, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0146 (e-mail: ent{at}hsc.vcu.edu).

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