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  Vol. 127 No. 4, April 2001 TABLE OF CONTENTS
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Graft-vs-Host Disease as a Cause of Enlargement of the Epiglottis in an Immunocompromised Child

Juan I. de Diego, MD; Maria P. Prim, MD; David Hardisson, MD; Antonio J. del Palacio, MD; Iaki Rabanal, MD

Arch Otolaryngol Head Neck Surg. 2001;127:439-441.

We report a rare case of dyspnea due to enlargement of the epiglottis in a severely immunocompromised patient. The child underwent a previous tracheostomy at another hospital because of respiratory distress under the diagnosis of acute epiglottitis. The patient was subsequently decannulated without incident. One year later, the child developed a new episode of dyspnea with inspiratory stridor. A new tracheostomy was neccessary, and a biopsy specimen of the enlarged epiglottis was taken to confirm the diagnosis of graft-vs-host disease. The therapeutic measures in these situations are discussed below, and a review of the current literature concerning the etiology and management of epiglottic enlargement is performed.


From the Departments of Otorhinolaryngology (Drs de Diego, Prim, del Palacio, and Rabanal) and Pathology (Dr Hardisson), La Paz Hospital, Autonomous University of Madrid, Madrid, Spain.

Corresponding author: Juan I. de Diego, C/Arzobispo Morcillo n 12, 1 C, 28029 Madrid, Spain (e-mail: jidediegomprim{at}retemail.es).



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