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Close Association of HLA-B52 and HLA-B44 Antigens in Israeli Arab Adolescents With Recurrent Aphthous Stomatitis
Lutfi Jaber, MD;
Abraham Weinberger, MD;
Tirza Klein, PhD;
Isaac Yaniv, MD;
Masza Mukamel, MD
Arch Otolaryngol Head Neck Surg. 2001;127:184-187.
Objectives To investigate the incidence and clinical features of recurrent aphthous
stomatitis (RAS) among Israeli Arab adolescents and to determine the HLA typing
profile in affected subjects.
Study Design Cross-sectional study.
Setting Junior high school in the largest Arab town in Israel.
Participants Four hundred seventy-seven Israeli Arab junior high school students
filled out a questionnaire. Students who reported more than 4 episodes of
RAS during the previous year were interviewed by telephone. Those whose responses
were confirmed were invited to the clinic. Of these, 22 were chosen at random
for HLA typing. Findings were compared with those in 117 healthy Israeli Arabs
who were candidate donors of bone marrow to patients at the Institute of Hematology–Oncology,
Schneider Children's Medical Center of Israel, Petah Tiqva.
Results Recurrent aphthous stomatitis was confirmed in 80 subjects (16.7%).
Of the 22 patients who underwent HLA typing, 7 (31.4%) had HLA-B52 antigens
and 8 (36.4%) had HLA-B44 antigens; corresponding figures for the control
group were 10 subjects (8.5%) (P = .007) and 9 subjects
(7.7%) (P = .001), respectively.
Conclusions There is a close association of HLA-B52 and HLA-B44 in Israeli Arab
youths with RAS. Long-term follow-up is needed to determine the relationship
between RAS and Behçet disease.
From The Bridge to Peace Community Pediatric Center, Taibe (Dr Jaber),
the Emergency Department and Day Care (Dr Jaber) and the Pediatric Rheumatology
Unit (Drs Jaber and Mukamel), Institute of Hematology– Oncology (Dr
Yaniv), Schneider Children's Medical Center of Israel, Petah Tiqva, and the
Department of Medicine B and the Felsenstein Medical Research Center (Dr Weinberger),
and Tissue Typing Laboratory (Dr Klein), Rabin Medical Center, Beilinson Campus,
Petah Tiqva, and the Sackler Faculty of Medicine, Tel Aviv University, Tel
Aviv, Israel (Drs Jaber, Weinberger, Klein, Yaniv, and Mukamel).
Corresponding author: Lutfi Jaber, MD, Box 27, Taibe 40400, Israel.
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Arch Otolaryngol Head Neck Surg. 2001;127(2):229-230.
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