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Pure Sesame Oil vs Isotonic Sodium Chloride Solution as Treatment for Dry Nasal Mucosa
Jörgen Johnsen, MD;
Britt-Marie Bratt, MD;
Oskar Michel-Barron, MD;
Christer Glennow, PhD;
Björn Petruson, MD, PhD
Arch Otolaryngol Head Neck Surg. 2001;127:1353-1356.
Objective To evaluate whether there was any difference in efficacy when nasal
mucosa dryness was treated with pure sesame oil (Nozoil) compared with isotonic
sodium chloride solution (ISCS).
Design In a randomized, crossover study, 79 subjects with nasal mucosa dryness
were enrolled. Half the subjects received pure sesame oil for 14 days followed
by ISCS for 14 days, and the other half received ISCS for 14 days followed
by pure sesame oil for 14 days. During the test period from March 13 to May
30, 2000, the outdoor absolute humidity was low. Nasal mucosa dryness, stuffiness,
and crusts were scored every evening with a visual analog scale.
Setting The County Hospital, Skellefteå, Sweden.
Results Nasal mucosa dryness improved significantly when pure sesame oil was
used compared with ISCS (P<.001). The improvement
in nasal stuffiness was also better with pure sesame oil (P<.001) as was improvement in nasal crusts (P<.001). Eight of 10 subjects reported that their nasal symptoms
had improved with pure sesame oil compared with 3 of 10 for ISCS (P<.001). Adverse events were few and temporary.
Conclusion When nasal mucosa dryness due to a dry winter climate was treated, pure
sesame oil was shown statistically to be significantly more effective than
ISCS.
From the Departments of Otorhinolaryngology, County Hospital, Skellefteå
(Drs Johnsen, Bratt, and Michel-Barron), Clinical Data Care, Lund (Dr Glennow),
and Otorhinolaryngology, Sahlgrenska University Hospital, Göteborg (Dr
Petruson), Sweden.
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