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Recent-Onset Bell Palsy Complicated by Diabetes
Comparison of Steroid and Lipoprostaglandin E1 Therapy
Tomoya Koriyama, MD;
Shigeru Inafuku, MD;
Kiyoko Kimata, MD;
Tatsuyuki Banno, MD;
Hiromichi Ishigami, MD
Arch Otolaryngol Head Neck Surg. 2001;127:1338-1340.
Objective To compare megadose steroid therapy (n = 17; group S) and lipoprostaglandin
E1 (lipo-PGE1) therapy (n = 14; group L) in patients
with recent-onset Bell palsy complicated by diabetes.
Design A nonrandomized controlled trial was performed. The 2 groups were almost
identical in age, sex distribution, and laterality, and there was no difference
in the average palsy scores in the 2 groups either at the time of the first
visit or when the palsy was at its worst.
Results There was no statistically significant difference in the cumulative
rates of improvement in the 2 groups 4 weeks, 2 months, or 6 months after
the first visit, revealing no difference in the therapeutic effects of the
2 agents. During the therapy, fasting blood glucose concentrations were increased
in all patients in group S, whereas they were not increased in group L. Complicated
diabetes was aggravated in group S, while it was not aggravated in group L.
Conclusions Lipo-PGE1 therapy may have improved vascular flow in the
facial nerves and accelerated recovery, resulting in a rate of improvement
comparable with that obtained through megadose steroid therapy. Lipo-PGE1 is a useful treatment method for patients with Bell palsy complicated
by diabetes.
From the Departments of Otorhinolaryngology, Nagoya Memorial Hospital,
Nagoya, Japan (Drs Koriyama and Kimata), and Department of Otorhinolaryngology,
Aichi Medical University, School of Medicine, Aichi, Japan (Drs Inafuku, Banno,
and Ishigami).
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Arch Otolaryngol Head Neck Surg. 2001;127(11):1403-1405.
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