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A Case Report and Literature Review

Shaozeng Zhang, MD, PhD; Tonia L. Farmer, MD; Mary Ann Frable, MD; Celeste N. Powers, MD, PhD

Arch Otolaryngol Head Neck Surg. 2000;126:672-674.

Rarely, adult herpetic laryngitis without involvement of the oropharynx has been reported. However, to our knowledge, laryngitis caused by herpes simplex virus with coexisting Candida albicans has not been reported. We report what we believe to be the first case of localized herpetic laryngitis superimposed by laryngeal Candida species infection in an immunosuppressed patient. This diagnosis was made on the basis of the findings of a laryngeal mucosal biopsy and ancillary testing using fungal stains and immunohistochemical stains for herpetic antigens. We also review the literature and discuss the clinical and diagnostic presentations, including potential pitfalls in the diagnosis.

From the Departments of Pathology (Drs Zhang and Powers) and Otolaryngology (Drs Farmer and Frable), Virginia Commonwealth University, Richmond.