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Harumi Jyonouchi, MD; Sining Sun, DDS; Frank L. Rimell, MD

Arch Otolaryngol Head Neck Surg. 2000;126:522-528.

Background  Chronic sinus inflammation may be determined partly by a balance of proinflammatory and counterregulatory cytokines and other mediators in the sinus. However, their mechanistic roles in chronic rhinosinusitis (CRS) are not well understood.

Objective  To evaluate production of proinflammatory (interferon [IFN-] and interleukin [IL] 12) and counterregulatory cytokines (IL-10 and IL-4) by sinus lavage (SL), bronchial lavage (BL), and peripheral blood mononuclear (PBMN) cells in patients with CRS.

Methods  We analyzed SL, BL, and PB samples obtained at surgery from 26 patients with CRS. Cytokine production was determined by culturing cells with or without stimuli. The results were evaluated in comparison with other inflammatory variables (cytologic findings, total protein, IgG, and lactose dehydrogenase), bacterial cultures, and clinical features.

Results  Production of IFN- by SL cells was variable and did not correlate with other inflammatory variables, microbes grown, IL-10/IL-12p40 production by SL cells, or IFN- production by BL or PBMN cells. Production of IL-4 by lavage cells was undetectable. None of 10 patients with elevated IFN- production (>800 pg/10⁶ SL cells with mitogen stimuli) had allergic rhinitis, whereas 12 of 16 patients with low IFN- production (<500 pg/10⁶ SL cells) had allergic rhinitis with positive reactivity to common aeoroallergens. There was no significant difference in other variables measured between low and high IFN- production groups.

Conclusions  Elevated IFN- production by SL cells may indicate much less possibility of allergic rhinitis in patients with CRS, but other variables measured did not differ in patients with high or low IFN- production by SL cells.

From the Departments of Pediatrics (Drs Jyonouchi and Sun) and Otolaryngology (Dr Rimell), School of Medicine, University of Minnesota, Minneapolis.

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Effects of Exogenous Interferon Gamma on Patients With Treatment-Resistant Chronic Rhinosinusitis and Dysregulated Interferon {gamma} Production: A Pilot Study
Jyonouchi et al.
Arch Otolaryngol Head Neck Surg 2003;129:563-569.
ABSTRACT | FULL TEXT  

Evidence of Dysregulated Cytokine Production by Sinus Lavage and Peripheral Blood Mononuclear Cells in Patients With Treatment-Resistant Chronic Rhinosinusitis
Jyonouchi et al.
Arch Otolaryngol Head Neck Surg 2001;127:1488-1494.
ABSTRACT | FULL TEXT