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A Novel Tumor Marker for Laryngeal Cancer

David A. Godin, MD; Philip C. Fitzpatrick, MD; Aline B. Scandurro, PhD; Peter C. Belafsky, MD, PhD; Brad A. Woodworth, BS; Ronald G. Amedee, MD; Derrick J. Beech, MD; Barbara S. Beckman, PhD

Arch Otolaryngol Head Neck Surg. 2000;126:402-404.

Objective  To determine whether levels of PH-20, a hyaluronidase similar to that found in human sperm, are elevated in laryngeal cancer tissue.

Design  In this case-control study, reverse transcription polymerase chain reaction was used to measure levels of PH-20 messenger RNA in tissue taken from laryngectomy specimens.

Setting  A university medical center.

Patients  We compared tissue samples taken from 11 patients with laryngeal cancer, and from 2 metastatic lymph nodes, with samples of normal, healthy laryngeal tissue and prostate cancer tissue (positive control).

Main Outcome Measure  PH-20 complementary DNA expression as quantified by densitometric analysis.

Results  Expression of PH-20 was significantly higher in nonirradiated laryngeal cancer specimens than in normal laryngeal tissue (P<.01). Metastatic lymph nodes also had higher levels of PH-20 expression than did primary laryngeal cancer tissue (P = .11) and normal laryngeal tissue (P<.01). Irradiated laryngeal cancer specimens had PH-20 levels comparable to normal.

Conclusions  We report the first data on PH-20 expression in laryngeal cancer tissue. PH-20 expression is significantly elevated in primary laryngeal cancer tissue and seems to be even higher in metastatic lesions compared with normal laryngeal tissue. PH-20 may be a useful tumor marker and prognostic tool for laryngeal cancer.

From the Departments of Otolaryngology–Head and Neck Surgery (Drs Godin, Fitzpatrick, Belafsky, and Amedee and Mr Woodworth), Pharmacology (Drs Scandurro and Beckman), and General Surgery (Dr Beech), and the Tulane Cancer Center (Drs Scandurro and Beckman), Tulane University School of Medicine, New Orleans, La.

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