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Mechanisms of Apoptosis and Its Role in the Pathology and Treatment of Disease

Sam P. Mostafapour, MD; David M. Hockenbery, MD; Edwin W Rubel, PhD

Arch Otolaryngol Head Neck Surg. 1999;125:729-737.

Objectives  To review recent advances in our understanding of programmed cell death, or apoptosis, and discuss implications of these basic science advances in our understanding of causes and potential treatments of a variety of diseases of the head and neck.

Data Sources  Basic science literature relevant to the study of apoptosis and its clinical implications.

Conclusions  Apoptosis is now understood to be important in the normal development and survival of all multicellular organisms. Deregulation of this normally tightly controlled process underlies a variety of disease states, including neoplasia, autoimmune disease, and disorders of the central nervous system. A better understanding of this process and its regulation may help otolaryngologists better understand diseases relevant to this specialty and will lead to improved therapeutic interventions.

From the Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology–Head and Neck Surgery, University of Washington School of Medicine (Drs Mostafapour and Rubel) and the Fred Hutchinson Cancer Research Center (Dr Hockenbery), Seattle, Wash.

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