 |
|
Intralesional Cidofovir for Recurrent Respiratory Papillomatosis in Children
Seth M. Pransky, MD;
Anthony E. Magit, MD;
Donald B. Kearns, MD;
D. Richard Kang, MD;
Newton O. Duncan, MD
Arch Otolaryngol Head Neck Surg. 1999;125:1143-1148.
Objective To assess the potential benefit of intralesional administration of cidofovir, an acyclic nucleoside phosphonate with activity against several DNA viruses, for treating severe respiratory papillomas in pediatric patients.
Design Prospective case series.
Setting Tertiary care children's hospitals.
Patients Five pediatric patients with severe recurrent respiratory papillomatosis requiring laryngoscopy with carbon dioxide laser therapy more frequently than once a month to maintain airway patency. Each patient underwent between 12 and 33 laryngoscopies with laser treatment prior to being injected with cidofovir.
Intervention Microsuspension laryngoscopy with intralesional injection of cidofovir (Vistide) in conjunction with mechanical debulking and carbon dioxide laser of papillomas.
Main Outcome Measure Papilloma stage at time of serial laryngoscopies.
Results One patient was disease free and 3 patients demonstrated a dramatic response to adjuvant therapy with cidofovir at the 9-month follow-up visit after the last injection of cidofovir. One patient showed an improvement in papilloma stage that was possibly related to concurrent therapy with interferon.
Conclusions Intralesional injection of cidofovir seems to be of benefit in the treatment of severe respiratory papillomatosis in pediatric patients. Larger prospective studies with longer follow-up will be required before cidofovir can be considered an accepted means of managing this difficult disease.
From Pediatric Otolaryngology, Children's Hospital and Health Center, San Diego, Calif (Drs Pransky, Magit, and Kearns); the Division of Otolaryngology, University of California, San Diego, School of Medicine (Dr Magit); the San Diego Naval Medical Center (Dr Kang); and Texas Ear, Nose & Throat Consultants, Houston (Dr Duncan).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Adult Intralesional Cidofovir Therapy for Laryngeal Papilloma: A 10-Year Perspective
Tanna et al.
Arch Otolaryngol Head Neck Surg 2008;134:497-500.
ABSTRACT
| FULL TEXT
Stability of cidofovir in extemporaneously prepared syringes
Hennere et al.
Am J Health Syst Pharm 2005;62:506-509.
FULL TEXT
Clinical Trial of Photodynamic Therapy With Meso-Tetra (Hydroxyphenyl) Chlorin for Respiratory Papillomatosis
Shikowitz et al.
Arch Otolaryngol Head Neck Surg 2005;131:99-105.
ABSTRACT
| FULL TEXT
Intralesional Cidofovir for Pediatric Recurrent Respiratory Papillomatosis
Mandell et al.
Arch Otolaryngol Head Neck Surg 2004;130:1319-1323.
ABSTRACT
| FULL TEXT
American Society of Pediatric Otolaryngology Members' Experience With Recurrent Respiratory Papillomatosis and the Use of Adjuvant Therapy
Schraff et al.
Arch Otolaryngol Head Neck Surg 2004;130:1039-1042.
ABSTRACT
| FULL TEXT
Predictors of Remission in Juvenile-Onset Recurrent Respiratory Papillomatosis
Ruparelia et al.
Arch Otolaryngol Head Neck Surg 2003;129:1275-1278.
ABSTRACT
| FULL TEXT
A Scheduled Protocol for the Treatment of Juvenile Recurrent Respiratory Papillomatosis With Intralesional Cidofovir
Chhetri and Shapiro
Arch Otolaryngol Head Neck Surg 2003;129:1081-1085.
ABSTRACT
| FULL TEXT
Stepped-Dose Protocol of Cidofovir Therapy in Recurrent Respiratory Papillomatosis in Children
Akst et al.
Arch Otolaryngol Head Neck Surg 2003;129:841-846.
ABSTRACT
| FULL TEXT
Successful treatment of severe respiratory papillomatosis with intravenous cidofovir and interferon {alpha}-2b
Armbruster et al.
Eur Respir J 2001;17:830-831.
ABSTRACT
| FULL TEXT
Clinical Update on 10 Children Treated With Intralesional Cidofovir Injections for Severe Recurrent Respiratory Papillomatosis
Pransky et al.
Arch Otolaryngol Head Neck Surg 2000;126:1239-1243.
ABSTRACT
| FULL TEXT
|
