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Jose E. Barrera, MD; Arlen D. Meyers, MD; Edward C. Hartford, MD

Arch Otolaryngol Head Neck Surg. 1998;124:1375-1376.

Toxic epidermal necrolysis is a severe dermatologic disorder clinically characterized by the acute onset of erythema and tenderness of the skin. Destruction of the epidermal barrier results in significant morbidity and mortality. Large erosions of mucous membrane, including the mouth and oral mucosa, are typical of toxic epidermal necrolysis. After ingesting naproxen sodium (Aleve) and aspirin, a previously healthy 43-year-old woman developed toxic epidermal necrolysis that resulted in hypopharyngeal stenosis complicated by dysphagia and recurrent aspiration.

From the Departments of Otolaryngology–Head and Neck Surgery (Drs Barrera and Meyers) and Surgery (Dr Hartford), University of Colorado Health Sciences Center, Denver.