 |
|
Phenylephrine and the Prevention of Postoperative Tympanostomy Tube Obstruction
Jerald S. Altman, MD;
Michael S. Haupert, DO;
Ronda A. Hamaker, MD;
Walter M. Belenky, MD
Arch Otolaryngol Head Neck Surg. 1998;124:1233-1236.
Objective To determine the efficacy of phenylephrine hydrochloride, a topical vasoconstrictor, in preventing tympanostomy tube obstruction.
Design Prospective, randomized, double-blind, controlled trial of patients undergoing myringotomy with tympanostomy tube insertion.
Setting Academic, tertiary referral medical center.
Patients Two hundred eight patients were enrolled in the study; 157 patients (310 ears) returned for postoperative evaluation.
Interventions Myringotomy with tympanostomy tube insertion was performed in all ears: 139 control ears received ototopical antibiotics and 171 treatment ears received ototopical antibiotics plus topical phenylephrine.
Main Outcome Measure Postoperative tympanostomy tube obstruction.
Results The overall incidence of tympanostomy tube obstruction was 5.2%: 8.6% in the control group and 2.3% in the treatment group. The treatment group demonstrated an odds ratio of 0.25 (95% confidence interval, 0.08-0.78; P=.02).
Conclusion The use of phenylephrine following tympanostomy tube insertion greatly reduces the incidence of tube obstruction.
From the Department of Otolaryngology–Head and Neck Surgery, Henry Ford Hospital, (Dr Altman) and the Department of Pediatric Otorhinolaryngology, Children's Hospital of Michigan, (Drs Haupert and Belenky), Detroit, Mich; and Pediatric Ear, Nose & Throat of Indiana, Indianapolis (Dr Hamaker). Dr Altman is now with Desert Ear, Nose and Throat, PC, Phoenix, Ariz.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Caution Advised When Using Diluted Phenylephrine Hydrochloride
Cunningham et al.
Arch Otolaryngol Head Neck Surg 1999;125:1170-1170.
FULL TEXT
|
