 |
|
Prognostic Significance of Nucleolar Organizer Regions in Adenoid Cystic Carcinomas of the Head and Neck
Xin Xie, MD;
Ståle Nordgård, MD;
Tore B. Halvorsen, MD;
Gunnar Franzen, MD;
Morten Boysen, MD
Arch Otolaryngol Head Neck Surg. 1997;123(6):615-620.
Abstract
| |
Objective
To determine the prognostic use of nucleolar organizing region (AgNOR) counts and clinical and histopathological features in adenoid cystic carcinoma.
Design
Argyrophilic staining was applied to ordinary formalin-fixed, paraffin-embedded specimens and evaluated to obtain the mean number of AgNORs and the percentage of nuclei with more than 1 (pAgNOR> 1), more than 2, more than 3, and more than 4 AgNORs.
Results
Using the log rank test, the mean AgNOR count showed no correlation with the disease-free period. All pAgNOR parameters exceeding the respective overall mean had poorer prognosis when compared with those below the mean (P=.02). The pAgNOR>l appeared as the best discriminator, singling out all treatment failures (P .001). This parameter also showed a high degree of intraobserver and interobserver reproducibility. Stage of the disease, violated resection margins, and presence of the histopathological solid subtype were markers of an unfavorable prognosis. Multivariate analysis by the Cox model showed that pAgNOR>1 (P.001) and tumor stage (P=.03) were the only statistically significant parameters.
Conclusions
Estimation of pAgNOR>1 is easy, quick, and highly reproducible. It may become a useful prognostic parameter in adenoid cystic carcinoma, but larger studies should be performed to confirm the reliability of this method.
Arch Otolaryngol Head Neck Surg. 1997;123:615-620
Author Affiliations
From the Department of Otolaryngology, National Hospital, University of Oslo, Oslo, Norway (Drs Xie and Boysen), and the Departments of Otolaryngology (Drs Nordgård and Franzen) and Pathology (Dr Halvorsen), University Hospital, University of Trondheim, Trondheim, Norway. Dr Nordgård is now affiliated with the Institute of Morphology, University of Trondheim.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Activation of Pregnane X Receptor Disrupts Glucocorticoid and Mineralocorticoid Homeostasis
Zhai et al.
Mol. Endocrinol. 2007;21:138-147.
ABSTRACT
| FULL TEXT
Prognostic relevance of cell proliferation in head and neck tumors
Pich et al.
Ann Oncol 2004;15:1319-1329.
ABSTRACT
| FULL TEXT
Urokinase-Type Plasminogen Activator Receptor Expression in Adenoid Cystic Carcinoma of the Skull Base
Doerr et al.
Arch Otolaryngol Head Neck Surg 2003;129:215-218.
ABSTRACT
| FULL TEXT
Adenoid Cystic Carcinoma of the Head and Neck: Predictors of Morbidity and Mortality
Fordice et al.
Arch Otolaryngol Head Neck Surg 1999;125:149-152.
ABSTRACT
| FULL TEXT
|
