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Rajendrakumar R. Ingle, MD; Gavin Setzen, MD; Peter J. Koltai, MD; Denise Monte, MD; Joseph Pastore; Timothy A. Jennings, MD

Arch Otolaryngol Head Neck Surg. 1997;123(3):297-300.

Abstract
Objective
p53 is a tumor suppressor gene that is lost or mutated in most forms of human malignancy. There are, however, very few studies evaluating p53 expression in normal epithelium or benign lesions.

Design
We screened for p53 protein expression in a variety of benign epithelial lesions of upper respiratory tract using monoclonal antibody DO-1 on paraffinembedded material.

Subjects
We studied a total of 109 cases: 16 cases of juvenile and 36 cases of adult laryngeal papillomatosis, 10 cases each of laryngeal nodules and laryngeal polyps, 17 cases of inverted papilloma, and 20 cases of nasal polyps.

Results
Nuclear immunoreactivity for p53 protein was demonstrated in 14 (88%) of 16 cases of juvenile laryngeal papillomatosis, 33 (92%) of 36 cases of adult laryngeal papillomatosis, 4 (40%) of 10 cases of laryngeal nodules, 8 (80%) of 10 cases of laryngeal polyps, 7 (41%) of 17 cases of inverted papilloma, and 2 (10%) of 20 cases of nasal polyps. These results pertained only to the basal epithelial layer in all cases of laryngeal nodules, laryngeal polyps, and nasal polyps. Intermediate layer cells were also positive for p53 in the majority of the cases of both juvenile (69%) and adult (75%) laryngeal papillomatosis and in a minority of the cases of inverted papilloma (18%).

Conclusions
Overexpression of p53 protein is commonly demonstrable in benign epithelial lesions of the upper respiratory tract. This observation suggests that p53 protein accumulation may occur in the absence of mutation of the

Arch Otolaryngol Head Neck Surg. 1997;123:297-300

Author Affiliations
From the Departments of Pathology and Laboratory Medicine (Drs Ingle and Jennings and Mr Pastore) and Surgery (Drs Setzen, Koltai, and Monte), Division of Otolaryngology—Head and Neck Surgery, Albany Medical College, Albany, NY.

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