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Matthew E. Beuerlein, MD; David E. Schuller, MD; Barry R. DeYoung, MD

Arch Otolaryngol Head Neck Surg. 1997;123(1):106-109.

Abstract
This is the first report (to our knowledge) that describes a patient with massive polyostotic fibrous dysplasia involving the calvaria and facial skeleton that subsequently underwent transformation to a malignant mesenchymoma with elements of chondrosarcoma, osteosarcoma, and rhabdomyosarcoma arising in the maxilla. Malignant transformation occurred in the absence of prior radiation exposure, osteomyelitis, or known bony infarction. A review of the literature did not reveal any similar cases of massive fibrous dysplasia of the maxilla degenerating to multiple simultaneous malignant histotypes.

Arch Otolaryngol Head Neck Surg. 1997;123:106-109

Author Affiliations
From the Comprehensive Cancer Center Head and Neck Oncology Program (Drs Beuerlein and Schuller) and the Departments of Pathology (Dr DeYoung) and Otolaryngology (Drs Beuerlein and Schuller), Arthur G. James Cancer Hospital and Research Institute, The Ohio State University, Columbus.

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