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Preliminary Experience With Thallous Chloride Tl 201—Labeled Single-Photon Emission Computed Tomography Scanning in Head and Neck Cancer
R. Theo Gregor, PhD, FRCS;
Renato Valdés Olmos, MD, PhD;
Wim Koops, MD, PhD;
Alfons J. M. Balm, MD, PhD;
Frans J. M. Hilgers, MD, PhD;
Cees A. Hoefnagel, MD, PhD
Arch Otolaryngol Head Neck Surg. 1996;122(5):509-514.
Abstract
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Objectives
To test the feasibility of single-photon emission computed tomography (SPECT) scanning with the use of thallous chloride Tl 201 in patients with head and neck cancer and to decide its possible applications to improve the diagnosis and staging of head and neck cancer.
Design
Findings from SPECT with the use of 4.32 mCi of thallous chloride Tl 201 were compared with those from clinical examination, computed tomography (CT), magnetic resonance imaging, ultrasound-guided fineneedle aspiration, and histologic studies. Primary sites and neck nodes were separately studied. Accuracy, sensitivity, and specificity were calculated for 19 patients who were being assessed for initial treatment (primary sites) and for 12 neck node dissections in 10 patients.
Setting
The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam.
Patients
A consecutive sample of 25 patients with head and neck cancers of different sites. The average age of the patients was 60.2 years, and there were 19 men and six women. The sites of the primary lesions were as follows: oropharynx (n=5), larynx (n=9), oral cavity (n=4), nasopharynx (n=1), hypopharynx (n=3), and unknown (n=3).
Results
For the primary lesions, SPECT identified 94% of the lesions; SPECT was more accurate in delineating four oropharyngeal lesions and one nasopharyngeal lesion. In 12 neck node dissections, SPECT identified all of the positive lesions and two negative lesions, whereas CT detected two false-positive lesions. Single-photon emission computed tomography gave less information about the number of nodes and the anatomy than did CT or magnetic resonance imaging.
Conclusions
Single-photon emission computed tomography with the use of thallous chloride Tl 201 appears to be useful in helping to identify occult primary lesions, particularly in the oropharynx. It may assist CT or magnetic resonance imaging in identifying a recurrence of cancer in tissues or in lymph nodes, and in screening for distant metastases. Although no nodes were identified that were not already seen with the use of CT or magnetic resonance imaging, SPECT may help to eliminate the false-positive lesions, and SPECT with the use of thallous chloride Tl 201 appears to be a valuable new tool in helping to diagnose and stage head and neck cancer.
(Arch Otolaryngol Head Neck Surg. 1996;122:509-514)
Author Affiliations
From the Departments of Otolaryngology—Head and Neck Surgery (Drs Gregor, Balm, and Hilgers), Nuclear Medicine (Drs Olmos and Hoefnagel), and Diagnostic Radiology (Dr Koops), The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam. Dr Gregor is now with the Department of Otolaryngology, University of Stellenbosch, Tygerberg Hospital, Western Cape, South Africa.
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