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Applications to Inner-Ear Genetics

Rick A. Friedman, MD, PhD

Arch Otolaryngol Head Neck Surg. 1996;122(3):252-257.

Abstract
With the advent of new and sophisticated molecular biological techniques, tremendous recent strides have been made in inner-ear genetics. The complexity of the mammalian genome and the paucity of genetic markers, however, have impeded rapid progress in the characterization of many inner-ear mutations at the molecular level. Transgenic technology, through insertional mutagenesis and targeted gene inactivation by homologous recombination, has provided a direct approach to the characterization of mutant phenotypes at the level of the gene.

(Arch Otolaryngol Head Neck Surg. 1996;122:252-257)

Author Affiliations
From the Division of Otolaryngology/Head and Neck Surgery, University of California, San Diego. Dr Friedman is now with the Division of Otolaryngology/Head and Neck Surgery, University of Cincinnati (Ohio).