This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Masashi Kato, MD; Taku Hattori, MD; Yoshinari Matsumoto, MD; Izumi Nakashima, MD

Arch Otolaryngol Head Neck Surg. 1996;122(12):1398-1400.

Abstract
Objectives
To define the dynamics of systemic and local soluble adhesion molecule levels and to discuss the role of these molecules in the pathogenesis of allergic rhinitis.

Design
Randomized control trial.

Subjects
Twelve volunteers with Japanese cedar pollinosis and 7 healthy volunteers.

Interventions
The levels of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble E-selectin, and soluble L-selectin in serum samples and nasal epithelial lining fluids (ELF) from 12 patients with pollinosis were measured 5 times throughout the allergy preseason to postseason, and the results were compared with those from 7 healthy subjects.

Results
The levels of sICAM-1 (P<.05) and sVCAM-1 (P<.05) in sera were up-regulated, and the levels of soluble L-selectin (P<.01) in sera were down-regulated during the early stage of the season in the allergic subjects. The difference between the levels of sICAM-1 and sVCAM-1 in sera in the early and midseason was statistically significant in the allergic subjects (P<.05). The levels of sICAM-1 in ELF were up-regulated during the early and mid-season. The levels of sVCAM-1, soluble E-selectin, and soluble L-selectin in ELF were undetectably low throughout the preseason to postseason.

Conclusion
There is evidence of the unique stage-dependent differential contributions of various soluble adhesion molecules in the pathogenesis of seasonal allergic rhinitis with a small amount of natural allergen provocation.

Arch Otolaryngol Head Neck Surg. 1996;122:1398-1400

Author Affiliations
From the Departments of Immunology (Drs Kato and Nakashima) and Dermatology (Dr Matsumoto), Nagoya University School of Medicine, Nagoya, Japan, and the Department of Otorhinolaryngology, Nagoya University Branch Hospital (Drs Kato and Hattori).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Local Levels of Soluble Tumor Necrosis Factor Receptors in Patients With Allergic Rhinitis Are Regulated by Amount of Antigen
Kato et al.
Arch Otolaryngol Head Neck Surg 2000;126:997-1000.
ABSTRACT | FULL TEXT  

IgE-Mediated Reactions and Hyperreactivity in Pregnancy Rhinitis
Ellegard and Karlsson
Arch Otolaryngol Head Neck Surg 1999;125:1121-1125.
ABSTRACT | FULL TEXT