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Richard J. H. Smith, MD; Diane K. Burke, RN; Yutaka Sato, MD; Rolland I. Poust, PhD; Ken Kimura, MD; Nancy M. Bauman, MD

Arch Otolaryngol Head Neck Surg. 1996;122(11):1195-1199.

Abstract
Objective
To assess the efficacy of OK-432 sclerotherapy in the treatment of lymphangiomas.

Design
Nonrandomized trial; follow-up, 4 to 29 months.

Setting
Academic tertiary referral medical center.

Patients
Six children with presumed lymphangiomas; age range at initial treatment, 1 month to 7 years 10 months.

Intervention
Fluoroscopically guided cyst aspiration, cystography, and injection of OK-432.

Outcome Measures
Clinical and radiographic comparisons before and after therapy.

Results
Complete response in 2 macrocystic lymphangiomas; no response in 3 microcystic lymphangiomas; and no response in 1 venous malformation.

Conclusion
OK-432 sclerotherapy may be effective treatment for macrocystic lymphangiomas.

Arch Otolaryngol Head Neck Surg. 1996;122:1195-1199

Author Affiliations
From the Departments of Otolaryngology (Drs Smith and Bauman and Ms Burke), Radiology (Dr Sato), and Surgery (Dr Kimura) and the College of Pharmacy (Dr Poust), University of Iowa, Iowa City.

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