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Carl H. Snyderman, MD; M. Motaz Abbas, MD; Robin Wagner; Frank D'Amico, PhD

Arch Otolaryngol Head Neck Surg. 1995;121(9):1017-1020.

Abstract
Objective
To determine the role of metabolites of arachidonic acid in the growth of squamous cell carcinomas of the head and neck.

Design
Investigation of the effect of a cyclooxygenase inhibitor, piroxicam, on the growth of squamous cell carcinoma in a murine model.

Intervention
C3H/HeJ mice bearing squamous cell carcinoma (SCCVII) were treated with piroxicam (0.08 mg/d, orally) for 30 days beginning 1 day before tumor inoculation.

Main Outcome Measures
Decrease in tumor volumes and tumor growth rates.

Results
Significant inhibition of tumor growth (P=.002) and final tumor weight (P=.0007) was noted in the group receiving piroxicam therapy. Prostaglandin E₂ levels in the tumor tissue were unrelated to treatment or tumor size. Increased levels of leukotriene B₄ were observed in the piroxicam-treated group (P=.03), and larger tumors were associated with decreased leukotriene B₄ levels (P=.0001).

Conclusions
Cyclooxygenase inhibitors may be effective in the treatment of some squamous cell carcinomas. The therapeutic effect of cyclooxygenase inhibitors may result from shunting into the lipoxygenase pathway of arachidonic acid metabolism.

(Arch Otolaryngol Head Neck Surg. 1995;121:1017-1020)

Author Affiliations
From the Department of Otolaryngology, University of Pittsburgh (Pa) School of Medicine (Drs Snyderman and Abbas and Ms Wagner); and the Department of Mathematics and Computer Science, Duquesne University, Pittsburgh, Pa (Dr D'Amico).

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