
Amyloidosis of the Head and NeckA Clinicopathologic Study of the UCLA Experience, 1955-1991
Marc M. Kerner, MD;
Marilene B. Wang, MD;
Gregory Angier;
Thomas C. Calcaterra, MD;
Paul H. Ward, MD
Arch Otolaryngol Head Neck Surg. 1995;121(7):778-782.
Abstract
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Objective To characterize the otolaryngologic manifestations of amyloidosis; classify patients with amyloidosis by specific location and type of underlying disease; and compare disease presentation and long-term outcome in these patients.
Design Retrospective review of biopsy specimens recorded as amyloidosis.
Setting Tertiary care referral center serving a diverse patient base.
Patients Of 141 patients with biopsy-verified amyloidosis who met the inclusion criterion for the study, 27 (19%) had head and neck manifestations.
Outcome Measures Good functional outcome and survival of patients with amyloidosis.
Results The tongue was the most commonly affected site of the head and neck. Distinct differences exist in functional outcome and long-term survival in patients with the localized form of amyloidosis when compared with patients with systemic amyloidosis.
Conclusion Because amyloidosis often affects the head and neck, otolaryngologists need to be familiar with this disease.
(Arch Otolaryngol Head Neck Surg. 1995;121:778-782)
Author Affiliations
From the Division of Head and Neck Surgery, School of Medicine, University of California—Los Angeles.
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