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A Clinicopathologic Analysis

Lewis R. Eversole, DDS, MSD; Dianne C. Duffey, MD; Nelson B. Powell, DDS, MD

Arch Otolaryngol Head Neck Surg. 1995;121(6):685-689.

Abstract
Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma. A review of 17 cases revealed that these tumors are aggressive, with a tendency to recur locally after surgery; they also may metastasize both regionally and distantly. There is a marked female predilection, and most cases are discovered during the fifth to seventh decades of life. Seventy percent occur in the mandible, appearing as poorly marginated radiolucencies. We conclude that this tumor is malignant and should be referred to as clear cell odontogenic carcinoma; it requires an aggressive surgical approach.

(Arch Otolaryngol Head Neck Surg. 1995;121:685-689)

Author Affiliations
From the Department of Oral and Maxillofacial Pathology, Section of Diagnostic Sciences, University of California—Los Angeles School of Dentistry and the Jonsson Comprehensive Cancer Center, Los Angeles, Calif (Dr Eversole); the Division of Head and Neck Surgery, University of California—Los Angeles School of Medicine (Dr Duffey); and Sleep Disorders Medicine, Stanford University School of Medicine, Palo Alto, Calif (Dr Powell).

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