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Rick M. Odland, MD, PhD; Alvin Umeda, DDS, MD; Scott Stevens; James Heinrich, MD; Mark Rowe, MD

Arch Otolaryngol Head Neck Surg. 1995;121(6):662-666.

Abstract
Objective
This is the first report (to our knowledge) of the use of tissue microdialysis to reduce tissue edema. In this study, a hyperosmotic solution was perfused through microdialysis catheters, allowing direct treatment of interstitial edema by osmosis.

Design
First, the catheter and perfusate characteristics were tested in vitro. A physiologic, controlled trial was then performed, with two outcome variables: osmolarity of the effluent and tissue water content.

Subjects
Twenty male Sprague-Dawley rats. One rat was withdrawn.

Interventions
Tissue microdialysis catheters were implanted in the rats. The control side of the animals was not perfused. The experimental side was perfused for 9 hours.

Results
Osmolarity of the perfusate was reduced 16.5 mOsm after passing through the catheter, indicating that fluid was removed from the tissue. Tissue edema was reduced by an average 1.8 mL of fluid per 100 g of wet tissue.

Conclusions
Tissue microdialysis removed tissue fluid and reduced edema. This treatment may have a beneficial effect on edematous tissues. Potential use and limitations of this therapeutic modality are discussed.

(Arch Otolaryngol Head Neck Surg. 1995;121:662-666)

Author Affiliations
From the Division of Otolaryngology—Head and Neck Surgery, Department of Surgery, Loma Linda University School of Medicine and the Jerry Pettis Memorial Department of Veterans Affairs Medical Center, Loma Linda, Calif.

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