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Marcel P. Copper, MD; Andreas Jovanovic, DDS; Jos J. P. Nauta, MSc; Boudewijn J. M. Braakhuis, PhD; Nico de Vries, MD; Isaac van der Waal, DDS; Gordon B. Snow, MD

Arch Otolaryngol Head Neck Surg. 1995;121(2):157-160.

Abstract
Objective
To determine the role of genetic predisposition in the etiology of head and neck squamous cell carcinoma.

Design
Retrospective study.

Setting
The outpatient clinics of the departments of otorhinolaryngology and maxillofacial surgery.

Patients
First-degree relatives of patients with new head and neck cancer, with first-degree relatives of the patients' spouses as controls.

Main Outcome Measure
Occurrence of cancer of the respiratory and upper digestive tract in relatives of patients with head and neck cancer and controls.

Results
First-degree relatives (n=617) of 105 patients with head and neck cancer had 31 cases of cancer of the respiratory and upper digestive tract vs 10 cases in the control group (n=618) (relative risk, 3.5; P=.0002). This higher rate of cancer was even larger in siblings (16 vs 2, relative risk, 14.6; P=.0001).

Conclusions
Genetic predisposition is an important risk factor for squamous cell carcinoma of the head and neck.

(Arch Otolaryngol Head Neck Surg. 1995;121:157-160)

Author Affiliations
From the Department of Otorhinolaryngology—Head and Neck Surgery (Drs Copper, Braakhuis, de Vries, and Snow), Department of Oral and Maxillofacial Surgery and Oral Pathology (Drs Jovanovic and van der Waal), and Department of Epidemiology and Biostatistics (Mr Nauta), Free University Hospital, Amsterdam, the Netherlands.

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